Objective? To compare the application effect of doxofylline and aminophylline in patients with bronchial asthma and the influence on the incidence of adverse reactions. Methods? A total of 148 patients with bronchial asthma admitted to the Department of respiratory medicine of Second People's Hospital of Dongying City，Shandong Province，from June 2018 to January 2020 were selected as the research objects and divided into two groups by random number table，with 74 cases each group. The patients in group A were treated with doxofylline，and patients in group B were treated with aminophylline. After 7 day treatment，the total effective rate，incidence of adverse reactions and lung function of the two groups were compared. Results? The total effective rate of group A 94.59% was higher than that of group B 83.78%（P＜0.05）；After 7 day of treatment， patients in group A had higher peak expiratory volume，forced vital capacity，and expiratory flow rate than those in group B（P＜0.05）；the levels of inflammatory cytokines IL-18，IL-33 and TNF-α in group A were lower than those in group B（P＜0.05）；the incidence of adverse reactions in group A was 6.76%，which was lower than that in group B 18.92%（P＜0.05）. Conclusion? Compared with aminophylline，doxofylline in patients with bronchial asthma has definite curative effect，which is helpful to promote the improvement of lung function and the remission of inflammatory reaction，and has higher safety.