目的 探讨消癌平片联合常规化疗方案对Ⅲ - Ⅳ期胃癌患者血清转化生长因子 -α（TGF-α）、血管内皮生长因子（VEGF）水平的影响。方法? 选取 2019 年 1 月至 2020 年 5 月无锡市锡山人民医院治疗的 60 例Ⅲ - Ⅳ期胃癌患者作为研究对象，按照随机数字法分为试验组和常规组，各 30 例。比较两组患者的治疗效果、治疗前后生存质量评分（KPS）、疼痛评分（VAS）及血清 TGF-α、VEGF 水平。结果? 试验组患者近期治疗有效率为 90.00%，高于常规组的 70.00%（P ＜ 0.05）；干预后试验组 KPS 评分、VAS 评分及血清 TGF-α、VEGF 水平均优于常规组（P ＜ 0.05）；关于毒副反应情况，两组无显著差异（P ＞ 0.05）；关于中、重度毒性反应发生情况，试验组白细胞减少及血红蛋白下降均为 0 例，对照组分别为 16.67％及 6.67％，试验组显著低于对照组（P ＜ 0.05）。结论? 消癌平片联合常规化疗方案可有效控制Ⅲ - Ⅳ期胃癌患者的病情进展，提高其治疗效果，值得临床应用推广。
Objective To investigate the effect of xiaoaiping tablets combined with conventional chemotherapy onTGF-α and VEGF in patients with stage Ⅲ-Ⅳ gastric cancer. Methods? Choose from January 2019 to May 2020，60 patients with stage Ⅲ-Ⅳ gastric cancer treated in Wuxi Xishan People's Hospital were taken as the research objects，according to the method of random numbers are divided into experimental group and routine group，30 cases each. The treatment effect，quality of life（KPS score），VAS pain score，serum TGF-α and VEGF levels before and after treatment were compared between the two groups. Results? The short-term effective rate of the experimental group was 90.00%，which was higher than that of the conventional group（70.00%，P＜0.05）. KPS score，VAS score，serum TGF-α and VEGF in experimental group were better than those in routine group（P＜0.05）. Regarding the toxicity profile，there were no significant differences between the two groups（P＞0.05）；with regard to moderate and severe toxic reactions，leukopenia and hemoglobin decrease in the experimental group were 0 case，while those in the control group were 16.67% and 6.67% respectively，which were lower in the experimental group than those in the control group（P＜0.05）. Conclusion? Xiaoaiping tablets combined with conventional chemotherapy can effectively control the progression of stage Ⅲ-Ⅳ gastric cancer and improve the therapeutic effect，which is worth popularizing.