Objective To explore the clinical characteristics，diagnosis and treatment methods and postoperative nursing of closed duodenal injury. Methods? Retrospective analysis was performed on the clinical data of 68 patients with closed duodenal injury diagnosed and treated by surgery in Hechuan District People's Hospital of Chongqing from January 2015 to January 2019. CT，X-ray，and ultrasound examination of symptoms in patients with early diagnosis and adopt suitable surgical procedure for surgical treatment in patients with closed duodenum damage，including duodenal repair surgery（gastrointestinal decompression，and stomach，jejunum colostomy）for removal of hematoma and duodenum jejunum and duodenum wall Roux - Y anastomosis，bowel resection duodenum injury，duodenal diverticulum and liver rupture repair，postoperative to give proper perioperative nursing to the patients. Results? Among the 68 cases of closed duodenal injury，65 cases were completely cured，the cure rate was 95.59%； there were 3 cases of severe complications in the process of postoperative and perioperative nursing，which eventually led to the death caused by multiple organ failure，the mortality rate was 4.41%. Conclusion? Appropriate early diagnosis，timely and reasonable surgical treatment and scientific perioperative nursing mode can effectively improve the cure rate of patients with closed duodenum and reduce the occurrence of complications and death.