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C-反应蛋白与血清白蛋白比值预测脓毒性休克患者发生急性呼吸窘迫综合征的价值分析
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2017年度磐安县科技计划项目(编号:磐科社202007)


The Value Analysis of the Ratio of C-reactive Protein to Serum Albumin in Predicting Acute Respiratory Distress Syndrome in Patients with Septic Shock
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    摘要:

    目的? 分析 C- 反应蛋白(CRP)与血清白蛋白(ALB)比值预测脓毒性休克患者发生急性呼吸窘迫综合征(ARDS)的价值。方法? 选取 2018 年 12 月至 2020 年 1 月浙江省金华市磐安县人民医院收治的 54 例脓毒性休克患者作为研究对象,根据入科室后第7 天是否发生 ARDS 将其分为 ARDS 组(20 例)与对照组(34 例)。对两组进行 CRP、ALB、血乳酸(Lac)、氧合指数(OI)检测,同时进行急性生理与慢性健康评分 II(APACHE II 评分)和序贯器官衰竭评分(SOFA 评分),比较两组的 CRP、ALB、CRP/ALB、Lac、OI、APACHEII 评分和 SOFA 评分,并分析 CRP/ALB 与 APACHE II 评分、SOFA 评分、Lac 和 OI 之间的相关性。结果? ARDS 组的 CRP、ALB 水平与对照组相当,差异不具备统计学意义(P > 0.05),而 ARDS 组的 CRP/ALB 值明显高于对照组(P < 0.05)。同时,ARDS 组的 Lac 水平、APACHE II 评分和 SOFA 评分明显高于对照组,其 OI 明显低于对照组(P < 0.05)。经 Person 相关性分析,ARDS 患者的 CRP/ALB 值与 APACHE II 评分、SOFA 评分和 Lac 水平呈正相关关系,与 OI 呈负性相关关系(P < 0.05)。结论? CRP/ALB 值在预测脓毒性休克患者发生 ARDS 中具有较高的应用价值。

    Abstract:

    Objective? To analyze the value of C-reactive protein(CRP)to serum albumin(ALB)in predicting acute respiratory distress syndrome(ARDS)in patients with septic shock. Methods? Totally 54 patients with septic shock admitted to Jinhua Pan'an People's Hospital from December 2018 to January 2020 were selected as the research objects. According to whether ARDS occurred on the 7th day after admission,they were divided into ARDS group(20 cases)and control group(34 cases). CRP,ALB,blood lactic acid(Lac),oxygenation index(OI),acute physiology and chronic health score II(APACHE II score)and sequential organ failure score(SOFA score)were performed in the two groups. CRP,ALB,CRP/ALB,Lac,OI,APACHE II score and SOFA score were compared between the two groups,and the correlation between CRP/ALB and APACHE II score,SOFA score,Lac and OI was analyzed.Results? The levels of CRP and ALB in ARDS group were similar to those in control group,the difference was not statistically significant(P>0.05),while the CRP/ALB value of ARDS group was significantly higher than that of control group(P<0.05). Meanwhile,Lac level,APACHE II score and SOFA score of ARDS group were significantly higher than those of control group,and oi of ARDS group was significantly lower than that of control group (P<0.05). By person correlation analysis,the CRP/ALB value was positively correlated with APACHE II score,SOFA score and Lac level,and negatively correlated with OI(P<0.05). Conclusion? CRP/ALB value has highapplication value in predicting ARDS in patients with septic shock.

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  • 在线发布日期: 2021-09-14
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