Objective?To explore the clinical value of metoprolol in the treatment of chronic heart failure patients with rheumatic heart disease. Methods?A total of 130 patients with chronic heart failure with rheumatic heart disease who were admitted to Zoucheng People's Hospital of Shandong Province from February 2017 to December 2019 were selected as subjects. By random number table method，the patients were divided into observation group and control group，65 cases in each group. The control group was treated with routine treatment，and the observation group was treated with metoprolol on the basis of the control group. The total effective rate，clinical symptom scores，improvemet of heart function and the scores of quality of life were compared between the two groups. Results?Compared with the control group（78.46%），the total effective rate of observation group（96.92%）was higher . After treatment，compared with the control group，the clinical symptom scores of the observation group were lower ，and the improvement of heart function indexes was more obvious. The scores of physical function，physiological function，physical pain，general health，vitality，social function，emotional function and mental health in the observation group were all higher than those in the control group（P＜0.05）. Conclusion?The application of metoprolol in the treatment of chronic heart failure patients with rheumatic heart disease can improve the therapeutic effect，effectively reduce the clinical symptoms of patients，and promote their cardiac function and quality of life to be significantly improved.