Objective?To explore the effect and safety of external fixation traction reduction combined with minimally Less Invasive Stabilization System (LISS) stell plate for tibial fractures on patients’ hemorheology. Methods?The clinical data of 83 patients with unilateral closed tibial fracture who underwent surgical treatment in Xuzhou Central Hospital from June 2015 to July 2019 were retrospectively analyzed, according to the different surgical methods, they were divided into group A (40 cases, underwent conventional open reduction and internal fixation with steel plate) and group B (43 cases, underwent intraoperative traction reduction with external fixation stent combined with LISS steel plate treatment), after the operation, patients in both groups were followed up for 9 months. The clinical efficacy at 9 months after operation, hemorheology index levels before and 1 month after operation and the occurrence of postoperative complications were compared between the two groups. Results?The total clinical effective rate of patients in group B was higher than that in group A at 9 months after operation; compared with preoperatively, the plasma viscosity (PV), low-cut whole blood viscosity and high-cut whole blood viscosity levels of two groups of patients decreased at 1 month after operation, and group B was lower than group A; the total incidence of postoperative complications in group B was lower than that in group A(all P<0.05). Conclusion?The treatment of tibial fractures with external fixator traction and reduction combined with LISS steel plate can improve the clinical efficacy of patients and improve the hemorheology of patients, and the safety is better.