Objective Analyze the effect of treatment with Metoprolol combined with Tongxinluo in patients with coronary heart disease and angina pectoris，comparing the safty between two groups. Methods?A total of 82 patients with coronary heart disease and angina pectoris admitted to Rizhao Hospital of Traditional Chinese Medicine from August 2019 to August 2020 were selected as the research objects. According to the random number table method，the groups were divided into control group and study group，with 41 cases in each group. All patients received routine treatment，and the control group received Metoprolol treatment in addition to conventional treatment. The study group was treated with Metoprolol combined with Tongxinluo on the basis of the control group. After two months of treatment，the clinical efficacy，blood lipid levels and adverse reactions were compared between two groups. Results?The total effective rate of the study group was 92.68%，which was higher than that of the control group （P ＜ 0.05）. Before treatment，there was no statistical significance in the level of blood lipid indexes between two groups（P ＞ 0.05）；After treatment，the levels of blood lipid indexes in two groups were improved，and the study group was better than the control group（P ＜ 0.05）；The incidence of ADR in the study group was 7.32% lower than that in the control group 19.51%（P ＜ 0.05）. Conclusion?Metoprolol combined with Tongxinluo has a significant effect on the treatment of coronary heart disease and angina pectoris. It can effectively improve the patients’blood lipid level，with few adverse reactions. It is worthy of clinical promotion and application.