Objective To observe the effects of Chinese medicine directional drug penetration therapy combined with acupuncture on the recovery of nerve and motor function and serum basic fibroblast growth factor (bFGF) and insulin-like growth factor-1 (IGF-1) levels in patients with acute cerebral infarction. Methods?A total of 100 patients with acute cerebral infarction admitted to Linyi Traditional Chinese Medicine Hospital from January 2019 to January 2020 were selected as the research objects, according to the random number table method, they were divided into the control group and the test group, with 50 cases in each group. Patients in the control group received conventional Western medicine treatment, and patients in the test group received Chinese medicine directional drug penetration therapy combined with acupuncture on the basis of the treatment in the control group. Patients in both groups received continuous treatment for 4 weeks. The recovery of nerve and motor function of the two groups of patients was compared, and the changes of serum bFGF, IGF-1 and cerebral hemodynamic indexes before and after treatment were compared. Results?After treatment, the scores of the National Institutes of Health Stroke Scale (NIHSS), vascular resistance (Rv) and dynamic resistance (DR) of the two groups of patients were lower than before treatment, and the test group was lower than the control group, and the motor function of the limbs Fugel-Meyer (FMA) score, average blood flow (Qm), average blood flow velocity (Vm), and serum bFGF and IGF-1 levels were higher than before treatment, and the test group was higher than the control group (all P<0.05). Conclusion?Chinese medicine directional drug penetration therapy combined with acupuncture can effectively improve cerebral hemodynamics in patients with acute cerebral infarction, increase the expression of serum bFGF and IGF-1 levels, and accelerate the recovery of patients' nerve and motor functions.