The Japanese Society of Gastroenterology revised the third edition of evidence- based clinical practice guidelines for peptic ulcer disease in 2020. The main contents of the includes hemorrhagic gastric and duodenal ulcers, H. pylori (Hp) eradication therapy, non- eradication therapy, drug- induced ulcers, non-Hp, and nonsteroidal anti-inflammatory drug (NSAID) ulcers, remnant gastric ulcers and Surgical treatment. The main points of the guideare now properly interpreted for reference.