Objective?To investigate the relationship between changes in plasma lipoprotein-associated phospholipase A2 （Lp-PLA2） concentrations and different types of coronary heart disease. Methods?40 patients and 60 healthy people Yanggu People's Hospital from April 2019 to April 2021 with coronary heart disease were retrospectively selected as the coronary heart disease group, According to different tyupes of coronary heart disease , coronary heard disease gronp was divided into stable angina pectoris group , unstable angina pectoris group and acute myocardial infarotion group. And 60 healthy people as the healthy group. The biochemical indicators of the subjects in each group were compared; The correlation between plasma Lp-PLA2 and other biochemical indicators in each group were compared. Results The levels of plasma Lp-PLA2 and hs-CRP in each group of patients with coronary heart disease group are higher than that of the healthy group（P ＜ 0.05）; unstable angina pectoris group and acute myocardial infarction group are higher than stable angina pectoris group （P ＜ 0.05）, and unstable angina pectoris group is lower than acute myocardial infarction group （P ＜ 0.05）; the levels of plasma Lp（a） in each group of patients with coronary heart disease group are higher than that of the healthy group（P ＜ 0.05）. The level of plasma Lp-PLA2 in the coronary heart disease group was positively correlated with serum hs-CRP （P ＜ 0.05）.Conclusion?Plasma Lp-PLA2, serum hs-CRP, and Lp（a） levels are highly expressed in patients with coronary heart disease, which indicates that the level changes can be used to judge the disease progression,and the level of hs-CRP in patients with coronary heart disease has a suggestive effect on the level of plasma Lp-PLA2.