Objective?To explore the efficacy and safety of different surgeries for gastrointestinal stromal tumors （GIST）.Methods?77 cases of GIST patients admitted in Xinyi People's Hospital from March 2019 to March 2021 were selected as research object and were divided into the experimental group （laparoscopic surgery, 39 cases） and the control group （open surgery, 38 cases）. The surgical success rate, surgery-related indicators, the postoperative Numerical Pain Rating Scale （NRS） score, gastrointestinal function [（gastrin （GAS）, motilin （MTL）], and complications were compared between the two groups. Results?Both groups of patients successfully completed the operation, histopathological examination confirmed negative margins, complete tumor resection, no conversion to open surgery in the experimental group, and the success rate of the operation was 100%. The blood loss during the operation of the experimental group was less than that of the control group （P ＜ 0.05）, and the postoperative exhaust gas, eating time, and postoperative recovery time were earlier than those of the control group （P ＜ 0.05）; the postoperative hospital stay was shorter than the control group （P ＜ 0.05）. Plasma GAS increased and MTL decreased in the two groups of patients after surgery, but the GAS of the test group was lower than that of the control group, and the MTL was higher than that of the control group. The differences were statistically significant （P ＜ 0.05）. The complication rate of the experimental group （5.13%） was lower than that of the control group （21.05%）, and the difference was statistically significant （P ＜ 0.05）. Conclusion?The success rate of laparoscopic surgery and open surgery were effective. Laparoscopic surgery for removal of gastrointestinal stromal tumors had less trauma, less bleeding, less interference with gastrointestinal function, fewer complications, and faster postoperative recovery, which had more advantages in clinical applications.