Objective?To analyze the application effects of two different approaches in patients with acetabular fractures and their effects on serum interleukin-6 (IL-6), C-reactive protein (CRP) and procalcitonin (PCT) levels. Methods?A total of 72 patients with acetabular fractures admitted to Binzhou Central Hospital from March 2018 to June 2021 were selected and divided into the control group (36 cases) and the observation group (36 cases) by the random number table method. The patients in the control group were treated with the operation through the ilioinguinal approach, and the patients in the observation group were treated with the operation through the modified Stoppa approach, and the patients in the two groups were followed up for 3 months after operation. The perioperative indicators, serum inflammatory factor levels before and 1 week after operation, scores of life quality before operation and 3 months after operation, joint function and fracture reduction 3 months after operation, and postoperative complications occurrence of patients in the two groups were compared. Results?The operation time, postoperative hospital stay, surgical incision length, and drainage tube extraction time of patients in the observation group were all shorter than those in the control group, and the intraoperative blood loss and postoperative drainage volume were all lower than those in the control group; 1 week after operation, the levels of serum IL-6, CRP and PCT of patients in the two groups were higher than those before operation, but the observation group was lower than the control group; 3 months after operation, the scores of the Brief Health Status Questionnaire (SF-36) in the two groups were higher than those before operation, and the observation group was higher than the control group; 3 months after operation, the excellent and good rate of joint function and fracture reduction satisfaction rate in the observation group were higher than those in the control group; the total incidence of complications in the observation group was 5.56%, while the total incidence of complications in the control group was 25.00%, the observation group was lower than thecontrol group (all P<0.05). Conclusion?The fracture reduction surgery with improved Stoppa approach can improve perioperative indicators, joint function, fracture reduction of patients with acetabular fractures, reduce inflammatory response, and improve patients' quality of life, and which has higher safety.