Objective?By detecting the level of procalcitonin (PCT) and statistical acute physiology and chronic health evaluation score (APACHE Ⅱ ), to study its value in judging the pathogen type and prognosis of patients with abdominal infection sepsis. Methods?A total of 90 patients with abdominal infection and sepsis in Shaanxi Provincial People’s Hospital from May 2017 to May 2021 were selected as the research subjects. According to different outcomes within 28 days, they were divided into death group (28 cases, patients died) and survival group (62 cases, patients survived) for retrospective analysis. The levels of serum PCT and APACHEⅡ were compared between the two groups. The re-ceiver operator characteristic (ROC) were used to analyze the value of PCT and APACHE Ⅱ score in judging the prognosis and pathogen types of patients. Results?The scores of serum PCT and APACHE Ⅱ in the death group were significantly higher than those in the survival group (P ＜0.05). The main pathogen was G- bacteria in the 90 patients with abdominal infection sepsis, which accounting for 66.67%, of which Escherichia coli was the most common, accounting for 40.00%. The AUC value of Gbacteria in patients with abdominal infection sepsis judged by PCT was 0.790 (SE=0.072, 95%CI=0.649~0.932, P=0.002), the sensitivity was 0.643 and the specificity was 0.903. The AUC value of APACHE Ⅱ to judge the 28 day mortality of patients was 0.767 (SE=0.070, 95%CI=0.629~0.904, P=0.004), the sensitivity was 0.933 and the specificity was 0.567. Conclusion?The PCT and APACHE Ⅱ scores are abnormally elevated in patients with abdominal infection sepsis. PCT is helpful to judge the type of pathogen infection, and APACHE Ⅱ score is helpful to judge the short-term prognosis.