《大医生》编辑部官网欢迎您!
加入收藏 | 设为主页 
血管生成素 2、C 反应蛋白与急性呼吸窘迫综合征并发急性肾损伤的相关性分析
DOI:
作者:
作者单位:

作者简介:

通讯作者:

中图分类号:

R322.6+1

基金项目:


Correlation analysis of angiopoietin 2, C-reactive protein and acute renal injury in acute respiratory distress syndrome
Author:
Affiliation:

Fund Project:

  • 摘要
  • |
  • 图/表
  • |
  • 访问统计
  • |
  • 参考文献
  • |
  • 相似文献
  • |
  • 引证文献
  • |
  • 资源附件
  • |
  • 文章评论
    摘要:

    目的?分析急性呼吸窘迫综合征(ARDS)并发急性肾损伤(AKI)的相关因素,探讨血管生成素 2(Ang2)、C 反应蛋白(CRP)与 ARDS 并发 AKI 的关系,分析 Ang2 和 CRP 的联合预测价值。方法?选取 2020 年 1 月至 2021 年 8 月普宁市人民医院收治的 80 例 ARDS 患者作为研究对象进行回顾性分析,根据是否并发 AKI 将其分为观察组(24 例, ARDS 并发 AKI)和对照组(56 例,ARDS 未并发 AKI)。采用多因素 Logistic 回归分析 ARDS 并发 AKI 的相关因素, 分析 Ang2 和 CRP 诊断 ARDS 并发 AKI 的价值。结果?多因素 Logistic 分析结果显示,机械通气(95%CI=1.304~3.608, P=0.003,OR=2.169)、血浆 Ang2(95%CI=1.623~3.305,P <0.05,OR=2.316)及血浆 CRP(95%CI=1.203~7.049, P=0.018,OR=2.912)是 ARDS 并发 AKI 的高危因素。受试者工作曲线(ROC)分析显示,血浆 Ang2(AUC=0.731, 敏 感 度 =0.833, 特 异 度 =0.500,P=0.022)、 血 浆 CRP(AUC=0.747, 敏 感 度 =0.833, 特 异 度 =0.679,P=0.014) 及联合预测(AUC=0.795,敏感度 =0.917,特异度 =0.607,P=0.003)诊断 ARDS 并发 AKI 风险具有较高准确性。 结论?Ang2、CRP 与 ARDS 并发 AKI 相关,联合检测血浆 Ang2 和 CRP 有助于诊断 ARDS 并发 AKI 风险。

    Abstract:

    Objective?To analyze the related factors of acute respiratory distress syndrome (ARDS) complicated with acute kidney injury (AKI), therelationship between angiopoietin 2 (Ang2), C-reactive protein (CRP) andARDS complicated with AKI were explored, and the combined predictive value of Ang2 and CRP were analyzed. Methods?The clinical datas of 80 patients with ARDS in Puning People’s Hospital from January 2020 to August 2021 were collected, the patients were divided into observation group (24 cases of ARDS complicated with AKI) and control group (56 cases of ARDS without AKI), which accorded to whether AKI was concurrent. Logistic multivariate analysis was used to analyze the related factors of ARDS complicated with AKI, and to analyze the value of Ang2 and CRP in judging ARDS complicated with AKI. Results?Logistic multivariate analysis showed that mechanical ventilation (95%CI = 1.304 ~3.608, P = 0.003, OR=2.169), plasma Ang2 (95%CI = 1.623~3.305, P < 0.05, OR=2.316) and plasma CRP (95%CI = 1.203~7.049, P=0.018, OR=2.912) were the high risk factors of ARDS complicated with AKI. The receiver operating char-acteristic (ROC) analysis showed that plasma Ang2 (AUC = 0.731, sensitivity = 0.833, specificity = 0.500, P=0.022), plasma CRP (AUC = 0.747, sensitivity=0.833, specificity=0.679, P=0.014) and joint prediction probability (AUC = 0.795, sensitivity=0.917, specificity=0.607, P=0.003) had high accuracy in judging the risk of ARDS complicated with AKI. Conclusion?Ang2 and CRP are related to the condition of ARDS complicated with AKI. The combined detection of plasma Ang2 and CRP is helpful to judge the risk of ARDS complicated with AKI.

    参考文献
    相似文献
    引证文献
引用本文
分享
文章指标
  • 点击次数:
  • 下载次数:
  • HTML阅读次数:
  • 引用次数:
历史
  • 收稿日期:
  • 最后修改日期:
  • 录用日期:
  • 在线发布日期: 2022-07-27
  • 出版日期: