Abstract:Objective?To explore the influencing factors of hyperuricemia (HUA) in aircrew,and provide reference for physical medical evaluation and health management. Methods?The clinical data of 7 685 cases of a Center from January 2017 to December 2020 were retrospectively analyzed, and they were divided into HUA group (1 612 cases) and non-HUA group (6 073 cases) according to whether they had HUA. The basic information of two sets of aircrew [gender, age, body mass index (BMI), history of hypertension, history of fatty liver, history of hypercholesterolemia and history of smoking] and laboratory index [triglyceride (TG), fasting blood glucose (FBG)] were collected and compared. ROC curve was used to analyze the value of BMI and TG in predicting HUA in aircrew. The risk factors of HUA in aircrew were determined by stepwise Logistic regression analysis. Results?The proportion of male, history of fatty liver, history of hypertension and history of hypercholesterolemia in HUA group was significantly higher than that in non-HUA group, and BMI and TG levels in HUA group were significantly higher than those in non-HUA group, with statistical significance (P < 0.05). According to ROC analysis, BMI ≥ 20.95 kg/m2 and TG ≥ 1.55 mmol/L were the best cut-off values for predicting HUA in aircrew with (P <0.05). Logistic stepstep regression analysis showed that history of hypertension, male, history of fatty liver, history of hypercholesterolemia, BMI≥ 20.95 kg/m2 , TG≥ 1.55 mmol/L were the risk factors for HUA in aircrew (P <0.05). Conclusion?History of fatty liver, male, history of hypertension, history of hypercholesterolemia, BMI≥ 20.95 kg/m2 , TG≥ 1.55 mmol/L are the risk factors for HUA in aircrew.