Objective?To study the clinical value of diffusion-weighted imaging (DWI) with various b values plus dynamic contrast enhanced magnetic resonance imaging (MRI) on diagnosis of breast carcinoma，and to provide reference for clinical diagnosis. Methods?A total of 83 patients with breast mass admitted to Wenchang People’s Hospital from July 2018 to June 2021 were selected as subjects. DWI with various b values and dynamic contrast enhanced MRI were performed. The diagnosis efficacy based on the combined examination was probed. Results?At different b values, apparent diffusion coefficient (ADC) for benign and malignant patients was not significantly different (P ＞ 0.05), but ADC in benign patients was higher than malignant patients (P ＜ 0.05). There was no significant difference in the time-signal intensity curve (TIC) distribution conditions between benign and malignant patients (P ＞ 0.05). The diagnosis sensitivity, specificity and accuracy based on combined examination was higher than DWI with various b values or dynamic contrast enhanced MRI (P ＜ 0.05). Conclusion?DWI with various b values and dynamic contrast enhanced MRI can increase the diagnosis accuracy, sensitivity and specificity of breast carcinoma patients. It is worthy of promotion.