Objective?To analyze the efficacy of lamotrigine dispersible tablets combined valproate in the treatment of pediatric epilepsy and effects on behavior and cognitive function, so as to provide some theoretical guidance for clinical antiepilepsy. Methods?A total of 43 children with epilepsy admitted to the First Naval Hospital of Southern Theater Command from December 2018 to June 2020 were selected and divided into treatment group (lamotrigine combined valproate, n=23) and control group (valproate combined carbamazepine, n=20) by random number table method. Comparison were made on clinical efficacy, occurrence of adverse reactions, the scores of the Rutter Child Scale and Loewenstein occupational therapy cognitive assessment(according to the Rutter child behavior questionnaire and LOTCA score) in two groups. Results?The difference between the treatment group total effective rate and the control group total effective rate was not statistically significant(P＞0.05). During drug therapy, the treatment group had lower incidence of adverse reactions than that in control group, and the difference was statistically significant (P＜0.05). After treatment, both groups had no statistically significant difference in the Rutter Child Scale (P＞0.05). The treatment group got higher scores in LOTCA, and had statistically significant difference (P ＜0.05). Conclusion?Lamotrigine combined valproate are effective in the treatment of pediatric epilepsy, with a low incidence of adverse reactions and an improvement in children’s behavior and cognition.