Objective To study the effect of low-profile visualized intraluminal support device (LVIS stent) -assisted coil embolization technique in the treatment of intracranial ruptured wide-neck aneurysm, in order to provide a clinical reference. Methods 88 patients with intracranial ruptured wide-neck aneurysm treated in the First Hospital of Fangshan District, Beijing from January 2017 to December 2021 were selected. According to random number table method, they were divided into control group and observation group, 44 cases in each group. Patients in control group were treated with coil embolization technique, and patients in observation group were treated with LVIS stent-assisted coil embolization technique. The postoperative efficacy, the level of vascular endothelial related indexes and the incidence of complications were compared between the two groups. Results The total effective rate of the observation group was higher at 6 months after surgery than that in the control group (P<0.05). The total effective rate of the observation group was higher at 12 months after surgery than that in the control group (P<0.05). After surgery, the levels of endothelin-1 (ET-1) and tumor necrosis factor-α (TNF-α) in two groups were lower than before surgery, the levels of nitric oxide (NO) and nitric oxide synthase (NOS) were higher than before surgery. The levels of ET-1 and TNF-α in observation group were lower than those in control group， the levels of NO and NOS were higher than those in control group (P<0.05). The complication rate of the observation group was lower than the control group (P<0.05). Conclusion LVIS stent-assisted coil embolization technique has good clinical effect in patients with intracranial ruptured wide-neck aneurysm, and can effectively improve the vascular endothelial function and reduce inflammation.