Objective To explore the effect of press needle therapy combined with lactulose on cancer pain patients with opioidinduced constipation (OIC) and its impact on quality of life, so as to provide reference for clinical practice. Methods The 100 cancer pain patients with OIC admitted to the Guangdong Second Traditional Chinese Medicine Hospital from April 2020 to March 2022 were selected as the research subjects, divided into control group and study group by random number table method, with 50 patients in each group. The patients in the control group were treated with lactulose oral liquid, and the patients in the study group were treated with press needle therapy on the basis of the control group. The overall clinical efficacy, constipation symptom score, severity of symptom scale (SSS) score, cleveland constipation scale (CCS) score, Bristol stool quality score, and constipation patient quality of life scale (PAC-QOL) score were compared between two groups. Results The overall clinical efficacy of the study group was better than that of the control group (P<0.05). After treatment, scores of difficulty in defecation, fecal characteristics, incomplete defecation of patients in two groups were lower than before treatment, and study group was lower than control group (P<0.05). After treatment, SSS and CCS scores of patients in two groups were lower than before treatment, and the study group was lower than control group (P<0.05). After treatment, the Bristol stool quality scores of patients in two groups were higher than that before treatment, and the study group was higher than control group (P<0.05). After treatment, PAC-QOL scores of patients in two groups were lower than before treatment, and the scores of patients in the study group was lower than that in the control group (P<0.05). Conclusion The combination of press needle therapy and lactulose has a significant clinical effect on cancer pain patients with OIC, and can improve the symptoms of constipation and improve the quality of life of patients, which is worthy of clinical application.