Objective To compare the efficacy of azithromycin combined with cefuroxime and ceftriaxone, respectively, in the treatment of bronchopneumonia in children. Methods The clinical data of 83 children with bronchopneumonia treated in the Second Affiliated Hospital of Guangzhou Medical University from March 2021 to March 2022 were retrospectively analyzed. According to the treatment methods, they were divided into control group (azithromycin alone, n=4), observation group A (azithromycin+cefuroxime, n=58) and observation group B (azithromycin+ceftriaxone, n=21). The curative effect and quality of life of the three groups were compared.At the same time, the clinical symptom scores of the three groups were compared before and after treatment, and follow-up for 6 months to compare the recurrence of the three groups.Results There was no significant difference in the total effective rate among the control group, observation group A and observation group B (P>0.05). There was no significant difference in the scores of fever and cough among the three groups before treatment (P>0.05). After treatment, the scores of fever and cough in the three groups were significantly lower, and the scores of fever and cough in observation group A and observation group B were significantly lower than those in the control group, while those in observation group B were significantly lower than those in observation group A (P<0.05). The quality of life scores of children in observation group A and observation group B were significantly higher than those in the control group, and the recurrence rate was significantly lower than that in the control group (P<0.05). Conclusion Azithromycin combined with cefuroxime and ceftriaxone is effective in treating children with bronchopneumonia, which can improve the quality of life of children and reduce the recurrence rate. Azithromycin combined with ceftriaxone can quickly and effectively relieve the clinical symptoms of children, and has certain advantages.